[Prostaglandins increase the response of intraocular muscle and outflow facility of the eye].

The function and sites of action of prostaglandins (PGs) vary in different animal species and tissues. In this study the effects of PGs (E1, E2, F2 alpha ,D2) on intraocular muscles and outflow facility of the eye were investigated, using enucleated bovine eyes. None of these PGs exogenously applied influenced the neuromuscular transmission. By contrast, after treatment with indomethacin, all PGs tested contracted the muscle much more than in the absence of indomethacin, and under these conditions the PGs potentiated responses to cholinergic nerve stimulation. Whereas PGF2 alpha was less potent in the absence of indomethacin, PGF2 alpha had more potent action primarily on nerves and partly on muscles after treatment with indomethacin. PGs also increased outflow facility of the eye, after the treatment with indomethacin. In order to understand the site and action of PGs, pretreatment with indomethacin may be useful in the intraocular muscle and outflow facility of the eye.